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‘It was only a make a difference of finding up a guide on mobile biology and beginning to study. I had originate from a globe of ultra-significant vacuums, cryostats and quantum phenomena, and now I was Doing work at home temperature with molecular biology kits.

I am able to rarely envision how I, like a geneticist, would be able to find out elementary physics, let alone contend at the top. How did you go over it?

2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and to start with ever research on the dynamics DNA supercoils and the invention of supercoil hopping

Our study ranges within the biophysics of DNA to artificial cells and past. Be sure to have a look below for the spectrum of our recent projects.

Size control of individual carbon nanotubes by nanostructuring with the scanning tunneling microscope

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The rotors harness Electricity from a nanoscale water and ion stream that is certainly generated by a static chemical or electrochemical opportunity gradient from the nanopore, that happen to be set up https://www.ceesdekker.net via a salt gradient or utilized voltage, respectively. These artificial nanoengines self-Manage and function autonomously in physiological disorders, suggesting solutions to constructing Electrical power-transducing motors at nanoscale interfaces.

Resolving the stage sizing in condensin-driven DNA loop extrusion identifies ATP binding given that the phase-generating approach

Since 2000 he moved to single-molecule biophysics and nanobiology, with analysis from experiments of DNA loop extrusion and supercoiling to DNA translocation via nanopores. A lot more not long ago his investigate has focused on studying chromatin construction and cell division with microorganisms on chip, when he is usually seeking to ultimately Develop synthetic cells from the bottom up.

‘That worries the synthetic cell, as Element of the Dutch BaSyC initiative. Craig Venter seemed best-down in those times and recognized about five hundred genes which have been minimally expected for any functioning mobile. We want to look base-up: how do we shift from the couple of molecules to an entire biological system?

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Supercoiling-dependent DNA binding: quantitative modeling and programs to bulk and solitary-molecule experiments